Each device have a "neighbors" field in advanced tab,
Since you are the one installed the hardware, you also know best which one may have issues and wich one not.
I do edit the neighbors field with nodeId's i know they solid and as best reachable by the edited device as possible.
As example. I have one inline smart switch installed in my breaker box.
The vera is about 20cm away from there in plain sight, and another switch is also in sight (trough a gipsum wall)
The network cleanup did add about 15 "neigbors" including some battery powered devices, which did make zero sense to me.
So i removed all and added just node 1 (the vera itself) and the switch nextto it
The speed of this switch did increase dramatically, so i have startet to do this with all devices i use.
Much less "mash" but very very fast responses.
Remember you need to put the Node-ids in this field and NOT the device ids!!
Also if too many devices irectly talk to the vera instead of using the mesh, vera starts to resend commands and wait for ack. So having all devices talk directly to the vera is also not super-smart.
But that is something youwill see on normal operation, if some devices lag or the vera keeps saying "waiting for ack"